National Secondary Route 243, or just Route 243 (Spanish: Ruta Nacional Secundaria 243, or Ruta 243) is a National Road Route of Costa Rica, located in the San José, Puntarenas provinces.

The road starts at the northeast in San Isidro de El General district and continues southwest to the Dominical beach area in the Pacific coast.

In San José province the route covers Pérez Zeledón canton (San Isidro de El General, Barú districts).

In Puntarenas province the route covers Quepos canton (Savegre district).

This article about a road in Costa Rica is a stub.