Documentation from a private meeting of the Augustinians on January 17, 1582, includes Fray Diego Ordoñez de Vivar as a signatory for Hagonoy.

[3] Fray Diego Ordoñez de Vivar erected parochial structures made of light materials in Barrio Quinabalon (now Barangay Santa Monica) and placed them under the guidance of Saint Anne.

Another church, built from 1815 to 1836 by Fray Juan Coronado, was destroyed by fire in 1856, which also damaged 30 houses in the town center.

Fray Manuel Alvarez, appointed parish priest in 1862, began constructing a larger church to accommodate more people.

The church walls were partially damaged by an earthquake in 1871, and repairs were made soon after under the leadership of Fray Ignacio Manzanares.

Secular priests from the Archdiocese of Manila began administering the church in 1900 after the Augustinian order evacuated due to the Filipino Revolution against Spain.

Further renovations occurred from 1968 to 1970 under Monsignor Jose B. Aguinaldo, who is attributed with the present façade featuring the predominant images of saints resting atop the pilasters.

[3] 1581 - The parish was founded by Augustinian missionaries (of the Order of St. Augustine, or OSA) as one of the first mission stations in what is now the province of Bulacan.

Fray Diego Ordoñez de Vivar, OSA, known for establishing the Augustinian missions from Western Bulacan to Southern Pampanga, served as the first minister of Hagonoy.

According to records, the parish was initially located at Quinabalon (from the Kapampangan word "balu," meaning "well-known"), which was then part of the pueblo of Calumpit.

1747 - The parish was rebuilt by Fray Eusebio Polo, OSA, at its current site, which, according to records, was on higher ground than the previous location.

At the back of the church's present site, the Augustinian friars would travel until they reached other parts of Bulacan and Pampanga.

Vicente B. Lina, Jr. 1871 - After being damaged by an earthquake, the parish church was renovated once again under the tenure of Fray Ignacio Manzanares, OSA.

1898 - At the peak of the Philippine Revolution against Spain, the last Augustinian curate of Hagonoy, Fray Emilio Bulliz, OSA, left the parish.

1970s - The church underwent further enhancements after the liturgical reforms of the Second Vatican Council under Hagonoeño parish priest Msgr.

As a result of these efforts, Malolos Bishop Cirilo R. Almario, Jr. decreed the Parish of St. Anne as a Diocesan Shrine on June 30, 1989.

During this time, significant renovations and developments were made, including the expansion of the parochial school to multiple campuses.

2015 - The “La Verdadera” or the original image of Saint Anne joined the Intramuros Grand Marian Procession for the first time.

Prior to the mid-20th century renovation, the church's façade was bare of ornamentation except for volutes at the ends of the imaginary triangular pediment, circular reliefs, and buttress-like pilasters capped with roof tiles.

The bell tower has minimal ornamentation, featuring only balustraded semicircular arch windows and buttresses at the corners.