It is situated next to the Minor Basilica of Our Lady of Immaculate Conception, the seat of the Roman Catholic Diocese of Malolos.

In 1934, the Holy Spirit Academy of Malolos once owned the land proper and named it Immaculada Academy that supports an exclusively for Girls school up until 1989 when Bishop Cirilo established an exclusive private boy school.

In 2013, the neighboring building of the Immaculate Conception School of Malolos whom then situated the Elementary Department until 2015 when Late Bishop Jose Oliveros D.D.

established the Senior High School Department, caught on fire in the middle of the night.

The Immaculate Conception School for Boys is always headed by the Bishop of Malolos.