It was and is still managed and administered by the Religious of the Virgin Mary (RVM), the first Filipino Congregation founded in 1684 by a Filipina, Mother Ignacia del Espiritu Santo.

Justina Martinez, Superior, and M. Dolores Verceles, Principal, managed to continue the school's operation by holding classes in private houses while a two-storey building was being constructed.

In August 1962, negotiations between the school and Mr. & Mrs. Vicente Floro paved the way for purchasing the lot on which St. Mary's College of Meycauayan now stands.

To meet the needs of the increasing school population, additional classrooms were constructed facing the MacArthur Highway.

The courses offered were Bachelor of Elementary Education (BEED) with specialization in preschool education, English, Filipino, Mathematics, Social Studies, Science and Health; Bachelor of Science in Commerce (BSC) major in accounting, Management, Financial Management, Marketing and Computer Applications.

Sabino Vengco blessed the Multi-Purpose Hall on January 22, 1989, in the presence of the RVM sisters, teachers, students, sponsors, and guests.

This Multi-Purpose Hall provides adequate space for school programs/activities, and PE classes and is shared with the public for seminars/workshops and other similar gatherings.

A significant event in 1989 was the launching the Movement for the Beatification of Mother Ignacia del Espiritu Santo by the RVM communities of SMCM and St. Mary's Academy of Sto.

Several programs were organized, namely: Income Generating Projects, Day Care, Emergency Assistance, Disaster Preparedness, Spiritual Uplift, Health and Sanitation.

These programs were wholeheartedly supported by the administrators, teachers, students, and parents through donations in kind and monthly pledges.

The laboratory, guidance, cashier, registrar, and administrative offices have been installed in the local area networking system.

For the grade school (GS), the provision of new kindergarten rooms was made possible with the support of donations from the Family Council.

In answer to the growing population of the college department and the opening of the Hotel and Restaurant Management (HRM) / Tourism Programs, a five-storey building was erected and finished in 1998.

In the same year, speech laboratories were installed for every department to respond to students’ needs to upgrade communication skills.

Likewise, lockers for individual students and drinking fountains were provided thus, contributing to making SMCM a more conducive place for learning.

This ISO certification by TUV Rheinland Berlin Brandenburg is in line with the reformulated vision and mission of SMCM which stresses the design, development and implementation of Basic and Higher Education services.

The college responded to the clamour of parents and senior students for the offering of the Nursing Program when it applied for a permit to operate on September 29, 2003.

In preparation for the offering of the BSN Program starting the school year 2004–2005, the Nursing Skills Laboratory was put up on the fifth floor of Our Lady of Lourdes Building.

On September 27–28, 2004, PAASCU representatives conducted a revisit of the grade school department after three (3) years from its initial accreditation.

To maximize the utilization of laboratories and further respond to community needs, the college offered short-term courses.

The Technical Education Skills Development Authority (TESDA) approved the Six-Month Caregiver Course on February 7, 2005, and the Food and Beverage Service on January 31, 2007.