NSBRI's 16,400-square-foot headquarters facility was located in the BioScience Research Collaborative in Houston, Texas.
The consortium was succeeded by the Translational Research Institute for Space Health (TRISH), led by the Baylor College of Medicine.
In 2016 NASA described the role of the collaboration as "investigat[ing] challenges of long-duration human spaceflight and bridg[ing] the expertise of biomedical community with the scientific, engineering, and operational expertise of NASA.
"[4] In 2010 and 2011, NSBRI was the only U.S. organization to participate in the Mars-500 Project's 520-day mission simulations with an experiment that monitored the six crew members' rest-activity cycles, performance and psychological responses to determine the extent to which sleep loss, fatigue, stress, mood changes and conflicts occurred during the mission.
The NSBRI Education and Outreach team won a Stellar Award from the Rotary National Award for Space Achievement Foundation in 2007 for "performance as a nationally recognized, top-tier program that is pioneering new models for exemplary teaching, training and public outreach in support of the Vision for Space Exploration.