[1] It was officially founded on 28 November 1949 and the opening play was Matej Bora's Night at the Globoko (Odrpanci), directed by Safet Pašalić.

It opened on 17 November 1951 as the first newly built theater building in Bosnia and Herzegovina after World War II, with a premiere of Hasanaginica directed by Sveto Milutinović.

Up until the start of the war in Bosnia and Herzegovina in 1992, the National Theatre Mostar produced 291 shows.

The last show, prior to the start of the war was Meša Selimović's Death and the Dervish directed by Ahmet Obradović.

The National Theatre Mostar hosts an annual comedy festival called Mostarska Liska.