[3] In order to avoid duplication of services, the government decided to make highly specialised units available at only two places, SGH and NUH.

The hospital added in a 200-bed, seven-storey tower ward block, eight operating theatres, and intensive care units over an area of 3.2 ha at a cost of S$100 million.

NUH was conferred the Joint Commission International (JCI) accreditation in August 2004 and the Singapore Service Class award in July 2004.

It also received a triple ISO certification:[4] In August 2007, Minister for Health Khaw Boon Wan announced plans to build two new national centres at NUH for heart and cancer treatments.

The National University Heart Centre, Singapore (NUHCS) announced its plans during a press conference on 2 December 2008 to improve its care and treatment for patients.

To meet the increasing and anticipated upward trend in healthcare demand, the infrastructure on the Kent Ridge campus will be developed to include extensive research and education facilities to be housed in the NUHS Centre for Translational Medicine building, and two national centres for Cancer and Cardiovascular Medicine at the NUH site.

In April 2014, the National University Cancer Institute, Singapore (NCIS) moved into the NUH Medical Centre, providing one-stop holistic and comprehensive care, management and treatment for both adult and paediatric oncology patients.