It was partially built under the authority of the Works Progress Administration; the crest of the WPA is visible in the sidewalks on the front campus.

In exchange for federal assistance, male student participation in the Junior Reserve Officers' Training Corps was mandatory until a few years after Kelly Walsh High School opened in 1965.

Natrona County High School was added to the National Register of Historic Places on January 1, 1994.

[4] In 2010–2011 the Natrona County School District began the process of a major re-design to reconfigure the site and renovate the historic building.

[10] In addition to standard core curriculum, NCHS offers courses in several areas of academic and technical specialty, including Agriculture, Automotive, DECA, FBLA, FFA, and JROTC.