In addition to her mainstream manga work, Ono publishes boys' love (male-male romance) comics under the pen name basso.
[1] Ono began creating dōjinshi (self-published manga) after graduating from high school.
Many of Ono's works have been published in English by Viz Media since 2010, including La Quinta Camera, Not Simple, House of Five Leaves, Ristorante Paradiso, the prequel series Gente: The People of Ristorante Paradiso, and the short story collection Tesoro.
[3] Ono is distinguished by her loose, minimalist drawing style,[4] and for the characteristic wide mouths of her figures.
[5] She typically writes slice of life stories focused on interpersonal relationships,[4] with travel used as a frequent plot and thematic device.