Natural Selection 2 is a multiplayer video game which combines first-person shooter and real-time strategy rules.

Like its predecessor, Natural Selection 2 features two opposing teams of players, Kharaa (Aliens) and Frontiersmen (Marines), seeking to destroy the other's respective base.

Both teams may have one player act as a commander, who is given a top-down view of the map and plays the game in a Real-time strategy perspective.

The commander can place buildings, research upgrades and has a number of abilities to support their team (dropping health and ammo packs, using certain support units to aid in combat or building, or erecting walls to block enemy movement), at the cost of resources.

Buildings in Natural Selection are designed to aid players in their offensive, defensive, stealth and speed capabilities.

They discuss the development process, funding and focus, and serve as a basis for interviews with other names in the industry.

[8][9][10][11] In October 2009, Unknown Worlds confirmed plans to support Mac OS X, Linux platforms and perhaps console.

[12] However, in February 2010, Max McGuire announced that OS X, Linux, and Xbox support would not be available at the game's initial launch.

[17] On February 14, 2023, Unknown Worlds Entertainment announced that the active development of Natural Selection 2 has ended.

[18] A few years after Natural Selection 2 was released, Unknown Worlds turned over development to a small team made up of community members.