Nebraska Highway 16

Its southern terminus is southeast of Bancroft at an intersection with NE 51.

Its northern terminus is at NE 35 south of Wakefield.

It heads in a northwesterly direction, intersecting NE 9 south of Pender.

It turns northward, running concurrently with NE 9 before splitting off to the west just north of Pender.

It ends at an intersection with NE 35 south of Wakefield.