Nebraska Highway 92 passes, follows, or runs through a number of the state's principal attractions, including Scotts Bluff National Monument, the Oregon Trail, Chimney Rock National Historic Site, Ash Hollow State Historical Park, Lake McConaughy, the Nebraska Sand Hills, and the City of Omaha.

Nebraska Highway 92 is the longest state route in the state at a total of 489.1 miles (787.1 km), and is part of a continuous 886-mile (1,426 km) four-state "Highway 92" which begins in Torrington, Wyoming, goes through Nebraska and Iowa and ends in La Moille, Illinois.

Starting in Scottsbluff, N-92, US 26, and the North Platte River form a three-way braid, crisscrossing one another several times for 91 miles (146 km) until Lewellen.

It then again overlaps US 26 a third time from there until Lewellen, where it separates to go through the resort communities along the north shore of Lake McConaughy until it meets N-61.

[1][2] It remains a four-lane suburban arterial street until it enters Iowa on the South Omaha Veterans Memorial Bridge over the Missouri River.