Its western terminus is at an intersection with Nebraska Highway 2 just south of Ravenna.

Its eastern terminus is at an intersection with Nebraska Highway 58 in Rockville.

Nebraska Highway 68 begins just outside the southern border of Ravenna at an intersection with NE 2.

Further north, it meets NE 82A before turning directly to the east.

The highway then head in a final northeasterly direction into Rockville where it will terminate at an intersection with NE 58.