Negro Creek rises about 2.5 miles southeast of Baynea, North Carolina in Alamance County, and then flows northeasterly into Caswell County to join Hyco Creek about 2 miles south-southeast of Hightowers.

[2] Negro Creek drains 8.05 square miles (20.8 km2) of area, receives about 46.5 in/year of precipitation, has a topographic wetness index of 362.36, and is about 54% forested.

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