The stream is considered to be a High-Quality Coldwater Fishery and Class A Wild Trout Waters.

Negro Hollow begins on a mountain known as Bears Head in Delano Township.

The stream then receives an unnamed tributary and turns north for several hundred feet, flowing through another valley.

The stream then turns east-northeast for a few tenths of a mile and reaches its confluence with Messers Run near the Blue Head Reservoir.

[2] Negro Hollow joins Messers Run 0.80 miles (1.29 km) upstream of its mouth.

[5] At 12:20 P.M. on July 22, 1997, the air temperature in the vicinity of Negro Hollow 0.28 miles (0.45 km) upstream of its mouth was 23 °C (73 °F).

[2] The lower reaches of the watershed of Negro Hollow are on rock of the Mauch Chunk Formation.

[4] The lower reaches of the watershed of Negro Hollow are on Leck Kill soil.

[4] There are Pennsylvania State Game Lands roads in the watershed of Negro Hollow.

[1] There is some land belonging to a Nature Conservancy Priority Forest Hub in the eastern part of the watershed of Negro Hollow.

The lower reaches of the watershed are in Pennsylvania State Game Lands Number 308.

[5] Negro Hollow is in the United States Geological Survey quadrangle of Delano.

[4] Two species of fish inhabit Negro Hollow: brook trout and sculpins.

These include American robins, hermit thrushes, Cooper's hawks, winter wrens, and pileated woodpeckers.