Primarily intended for the European and Latin American market as the larger counterpart of the Neoplan Skyliner, it was built on lessons learnt from the experimental Neoplan Jumbocruiser.

Some Megaliners also saw service mainly as overnight long-distance coaches in Japan.

On 28 May 2008, in Japan one of two Neoplan Megaliners operated by West JR Bus Company caught fire while in service, and burnt down completely.

[1] On 16 March 2009, in Japan one of two Megaliners operated by JR Kanto Bus Company caught fire on an overnight Seishun Mega-Dream Go service between Osaka and Tokyo.

The 77 passengers and driver evacuated safely before the coach was completely destroyed.