[2] It is believed that the first white settler in what is now Nescopeck Township was George Walker (in 1786).

The early settlers were frequently harassed by Native Americans.

The largest hamlet in the township, which is now the Borough of Nescopeck, was established on the site of a former Delaware settlement (which was a rendezvous for the Native Americans during the French and Indian War).

The Susquehanna River defines the northern border of the township.

Nescopeck Mountain, a forested ridge, defines the southern border of the municipality.

Nescopeck Creek flows through the western half of the township.

Briggsville and Zenith are two small farming communities located within the interior of the township.