Neso Lake is a glacial lake on the Mistik Creek chain in the Hudson Bay drainage basin in the Northern Region of Manitoba, Canada.

It sits in the Churchill River Upland portion of the Midwestern Canadian Shield forests which consist of mixed coniferous forest trees.

[1] The region around the lake consists of rocky parallel ridges with poorly drained areas of muskeg and irregular rocky shorelines due to intense glaciation.

[2] The lake is situated on the well known "Mistik Creek Loop", a remote canoe route which is 95 km (59 mi) in total length and can be paddled in four days.

[3][4] There is a fishing lodge[5] and a provincial park[6] located on the lake.