The synagogue was established in 1980 for the immigration of Persian Jews to Los Angeles County, shortly after the Iranian Revolution of 1979.

[3] The congregation moved into its current building (the former home of the First Church of Christ, Scientist[4] that now resides across the street) in 2002.

[5] It includes "Simcha Hall", a ballroom used for weddings, Bar/Bat Mitzvah, Brit milah, fundraising events, etc.

[6] It acts as a large religious, educational and cultural center, where Hebrew and Iranian Jewish history is taught.

[2] A 2011 profile of Nessah Synagogue in Tablet Magazine found that the congregation serves an important function as a "community center" for the Persian Jews of Los Angeles and as a bridge between traditions rooted in Iran and the mainstream American lifestyle most of them now lead, and also noted that many members maintain affiliation both with Nessah and with another congregation with a more mixed membership, such as Sinai Temple or Stephen S. Wise Temple.