It is a joint effort between Pandey Lab at the Johns Hopkins University and the Institute of Bioinformatics (IOB), Bangalore, India,[2] and is also worked on by other parties.

The 45 pathways contain information pertaining to protein-protein interactions, enzyme-protein substrate reactions which bring about post translational modifications (PTMs) and also a catalogue of genes which are differentially regulated upon activation of specific ligand mediated receptor pathways.

The molecules which localises to different cellular organelles due to their PTMs or specific protein-protein interactions which occur downstream of ligand-receptor mediated pathway are available under translocation events.

Recently, NetPath has also curated the molecules involved in the transcriptional regulation of genes in the context of immune signaling pathways.

The reactions in NetPath are curated by PhD level scientists from experimental evidence available in published research articles.