[2] Major railroad infrastructure, known as the Milwaukee Junction, was built in the 1890s to facilitate industrial expansion in the city of Detroit.

Although not part of the New Amsterdam Historic District, part of the early industrial character of the area was formed by the enormous Albert Kahn-designed Burroughs Adding Machine factory at Second and Burroughs, which is now the Henry Ford Health Systems administrative offices.

[6] Cadillac moved their production to the Clark Street plant in Southwest Detroit in 1920, after which Wescott Paper and other tenants leased the building.

[3] Beginning in the late 1920s, the Jerry McCarthy Chevrolet Company operated a dealership and service center out of this building.

[11] C. F. Carney and Joseph Labadie formed the Carney-Labadie Company in 1910 to distribute Exide batteries and Firestone tires.

The six-story Cadillac Sales and Service Building was designed by Albert Kahn[11] and built in 1927; it originally contained offices and a showroom.

[5] The building has now been restored and converted into a WeWork, which offers beautiful spaces for collaboration, community, and events, .

[16] The building was demolished in August 2012[17] in order to construct the third phase of TechTown,[11] a nearby biomedical research center.

The building is part of a $93-million rehabilitation project planned by nearby Wayne State University;[3] it will be converted into a biomedical research center.

[15] The Engine 17 and Ladder 7 companies were originally organized on June 17, 1893, at the corner of Cass and Amsterdam.

[22] After renovation, the schools moved the Detroit Children's Museum from its Midtown location to the site.

[23] The brothers built the company to become one of the largest penny slot makers in the world,[23] employing over 400 people in 1912.

[24] Later they expanded their product line to include other items such as marine motors, scales,[23] and the conveyor belts used in grocery stores.

[25] This building on the corner of Cass Avenue and York Street has been demolished by Wayne State University.