The Jefferson–Chalmers Historic Business District is a neighborhood located on East Jefferson Avenue between Eastlawn Street and Alter Road in Detroit, Michigan.

In 1851, a plank road was built along Jefferson, from Detroit to Grosse Pointe, with a toll bridge over Fox Creek.

Roadhouses were built along the road including, by 1876, a saloon, located on the south side of East Jefferson Avenue near Fox Creek, within what is now this historic district.

[4] In 1874, draining of the surrounding swamp began in earnest, spurred in part by prominent Detroit attorney William B. Moran, who owned much of the land.

That same year, the land in the district began to be subdivided, and by 1893, a number of streets crossing Jefferson had been platted.

New development continued in the surrounding neighborhoods into the 1920s, spurred by the Chrysler Motor Company's construction of a huge nearby factory.

[4] The Great Depression ended the construction boom in the district, but business began to revive later in the 1930s with the establishment of stores in the area.

The Jefferson–Chalmers area continued to thrive through the 1940s and 1950s, but in 1954 the nearby Hudson Motors plant closed, starting a slow decline in economic fortunes.

[7] Recently Kathy Makino-Leipsitz, owner of Shelborne Development, completed full rehabilitations on three buildings located on Jefferson Avenue opening up 49 - 1, 2 & 3 bedroom apartments.