Route 380 is a 29-kilometre (18 mi) long mostly east–west secondary highway in the northwest portion of New Brunswick, Canada.

The route's North-Eastern terminus is north-east of the community of Limestone.

The road then takes a sharp turn north to the community of New Denmark Corner.

The road again makes a sharp turn this time towards the south-east passing Outlet Brook before entering the community of Bell Grove.

The road then switches direction to the south-west again then enters the community of Merritt Lake.