From Riverview, Route 112 uses the Coverdale Road along the south bank of the Petitcodiac River, passing through Middle Coverdale, Upper Coverdale, and Five Points before crossing the river at Salisbury.

Route 112 crosses the Canaan River and then follows its west bank in a southwesterly direction to the road's end at Coles Island.

Between Coles Island and Salisbury, where Route 112 intersects the Trans-Canada Highway, Route 112 was a popular shortcut for travellers between the Fredericton and Moncton areas.

In the Fredericton area, it was colloquially referred to as the "Coles Island Road".

However, with the opening of the upgraded four-lane Trans-Canada Highway in 2001, Route 112's importance as a trans-provincial highway link has diminished.