Route 133 is a mostly east/west provincial highway in the Canadian province of New Brunswick.

The road is a continuation of Route 134 in Gilberts Corner.

The road has a length of approximately 28 kilometres, and services small, otherwise isolated rural communities.

In these areas, the highway is often unofficially referred to as "Main Street."

The road runs mostly between the Northumberland Strait and Route 15 and a small portion of Route 11 in Greater Shediac.