This route provides weekday service between Fort Totten and New Carrollton stations without having to take the train into Downtown DC.

Route J2 originally operated as part of the "East - West Highway" Line all the way between Montgomery Mall and Beltway Plaza, while Route J4 originally operated as part of the "East - West Highway" Line all the way between Chevy Chase Circle and Beltway Plaza.

[3] The segment of F6's former routing between the intersection of Campus Drive & Adelphi Road (University of Maryland College Park Campus) and Greenbelt Center (Crescent Road & Gardenway), was taken over by the C2 Metrobus Route.

[3] However; F6 was forced to temporarily stop operating on its usual routing between the Prince George's Plaza Shopping Center and University of Maryland College Park Campus, via Belcrest Road, Adelphi Road, and Campus Drive, as Paint Branch Parkway was not finished being constructed between the intersections of Baltimore Avenue (where Campus Drive ends) and River Road, at the time.

On September 20, 1999, F6 was once again extended back to its original terminus at the Silver Spring Station, following its usual routing between the New Carrollton station and intersection of Ager Road & East-West Highway in Green Meadows, MD, then operating on its original routing to the Silver Spring station parallel to the F4 Route, via East-West Highway, Ethan-Allen Avenue, Philadelphia Avenue, Fenton Street, and Colesville Road.

Routes F4 and F6 stopped directing entering into and looping inside the Prince George's Plaza.

[5] On September 28, 2008, due to the Silver Spring station Bus Bay and Kiss & Ride Lot were closed off due to the construction of the brand new Silver Spring Transit Center, routes F4 and F6 Metrobus Stop at Silver Spring was temporarily relocated from Bay N, to the jughandle at the intersection of Wayne Avenue and Colesville Road, across Silver Spring station until September, 2015 when the Paul S. Sarbanes Transit Center was finished being constructed and officially opened.

[7] This was proposed in order to reduce redundancy with F4 between Silver Spring station and the East West Highway and Riggs Road intersection.

As of a result, route F6's bus stops were moved onto River Road in order to serve the station.

[11] All route F6 service was suspended due to WMATA's response to the COVID-19 pandemic beginning on March 16, 2020.