During the team's first season in Manchester, the Fisher Cats played at Gill Stadium, a historic ballpark in a residential neighborhood.

They next won the Eastern League championship in 2011, their first season wearing their current red, white, and blue team color scheme, and again in 2018.

[citation needed] The team was sold on January 27, 2003, to Lowell Spinners owner Drew Weber, with the intention of moving the franchise to Manchester, New Hampshire.

The first season was played at Gill Stadium southeast of the downtown area while the current ballpark was under construction.

Travis Snider of the Fisher Cats won the Home Run Derby over Luis Montanez of the Bowie Baysox 7–6.

[citation needed] On May 21, 2012, three Fisher Cats pitchers combined to throw the third no-hitter in franchise history, stifling the Portland Sea Dogs in a 6–0 victory at New Hampshire.

Combining on the gem for the team were Brett Cecil (5⅔ innings), Danny Farquhar (2⅓), and Ronald Uviedo (1).

[11] In 2022, the Double-A Northeast became known as the Eastern League, the name historically used by the regional circuit prior to the 2021 reorganization.

[12] On November 6, 2003, the new management unveiled the New Hampshire Primaries name and logo, which featured an elephant and a donkey holding baseball bats, and was to be used starting in the 2004 season.

On January 22, 2004, the team unveiled the new set of logos that would be used for the name New Hampshire Fisher Cats.

[citation needed] On August 25, 2007, the Fisher Cats held a "turn back the clock" promotion and played as the New Hampshire Primaries against the Portland Sea Dogs.