It runs 34.64 mi (55.75 km) as an outer bypass of the Camden area from an intersection with U.S. Route 322 (US 322) in Folsom, Atlantic County, north to the Tacony–Palmyra Bridge in Palmyra, Burlington County, where the road continues into Philadelphia, Pennsylvania, as Pennsylvania Route 73 (PA 73).

The road runs through forested areas of the Pine Barrens with some homes and farms, coming to a crossroads with Route 54.

Following this intersection, the road continues northwest as Mays Landing Road, crossing the Beesleys Point Secondary railroad line operated by the Cape May Seashore Lines railroad at-grade.

[1][3] It enters a small corner of Hammonton before it heads into Winslow Township in Camden County.

It heads to the north as a four-lane undivided road, passing through wooded areas with some residences and businesses and crosses CR 723, which provides access to the westbound Atlantic City Expressway and from the eastbound Atlantic City Expressway.

The route continues to an intersection with CR 561, where it briefly widens into a four-lane divided highway.

[1][3] A short distance later, the route enters Waterford Township and comes to a modified cloverleaf interchange with US 30 (White Horse Pike) and CR 536 Spur.

[1] Following US 30, Route 73 passes through a small corner of Berlin Boro before it goes under NJ Transit's Atlantic City Line west of the Atco station.

[1][3] At the railroad underpass, the route enters Berlin Township and meets CR 534 at a crossroad.

[1] From here, the road turns north and reenters Berlin Township as a four-lane divided highway, continuing through developed areas and intersecting CR 692.

[1] After Route 41, the road intersects CR 610 and bypasses the center of Maple Shade to the east as a four-lane divided highway.

[1][3] Route 73 briefly enters Cinnaminson Township, Burlington County, again before crossing into Palmyra at the bridge over the Pennsauken Creek.

[1] In Palmyra, the road has an interchange with CR 543 before running under NJ Transit's River Line.

[7] It has been rated one of the worst roads in the state in terms of traffic, accidents, and driver aggression.