The road crosses a set of railroad tracks used by NJ Transit's River Line and Conrail Shared Assets Operations.

[1][2] Upon crossing the Pennsauken Creek, CR 543 enters Palmyra in Burlington County and immediately comes to an interchange with Route 73.

The route intersects CR 601 and turns northwest onto Public Road, passing residential and industrial areas.

CR 543 crosses the River Line and immediately turns northeast onto Broad Street.

In Riverside Township, the route passes more commercial developments, becoming Lafayette Avenue at the Fairview Street intersection, which narrows to two lanes.

CR 543 turns north onto Pavilion Avenue near the Riverside Station and passes through residential and commercial areas.

Here, CR 543 turns east and passes more residences before leaving Beverly for Edgewater Park Township.

Upon entering, Burlington Township, the route becomes Beverly Road and passes residential and commercial development before intersecting US 130.

The road comes to a partial interchange with US 206 and soon intersects CR 690 in the residential community of Columbus, which it passes through as Main Street.