New Melle is a small city in St. Charles County, Missouri, United States.

[4] The community was named after Melle, Germany, the former home of a share of the first settlers.

[7] The Meier General Store and St. Paul's Church are listed on the National Register of Historic Places.

There were 195 housing units at an average density of 124.2 per square mile (48.0/km2).

The racial makeup of the city was 97.3% White, 0.6% African American, 0.8% Asian, 0.2% Pacific Islander, and 1.1% from other races.

17.3% of all households were made up of individuals, and 10.6% had someone living alone who was 65 years of age or older.

15.9% of all households were made up of individuals, and 9.1% had someone living alone who was 65 years of age or older.

There were no families and 3.1% of the population living below the poverty line, including no under eighteens and none of those over 64.