The southern terminus of NM 460 is at the Texas state line in the town of Anthony where SH 20 ends.

The northern terminus is south of Berino where it ends in a T-intersection with Frontage Road 1035 (FR 1035) on the west side of Interstate 10.

Continuing north, the highway enters the southern outskirts of the community of Berino, and reaches its northern terminus at intersection with FR 1035 west of the former I-10 exit 160.

I-10 was then built over the new alignment and extended south into Texas in late 1950s with exception of a short spur angling west towards Anthony.

Some time around 2000 this interchange was eliminated, probably to allow construction of a large NM Truck Port of Entry roughly at this location.