U.S. Route 80 (US 80) was a major transcontinental highway in the U.S. state of New Mexico from November 11, 1926, to October 12, 1991.

Nationally, US 80 stretched from San Diego, California to Tybee Island, Georgia, going through southern New Mexico from El Paso, Texas, through the towns of Las Cruces, Deming and Lordsburg before entering Arizona.

After 1956, US 80 followed present day NM 460 and the western I-10 frontage road, before rejoining the older alignment in Las Cruces.

[3] Originally, US 80 continued north on Main Street through the heart of downtown Las Cruces.

NM 549 passes over the Union Pacific Railroad at the ghost town of Cambray before continuing northeast for a few miles before intersecting again with I-10.

The roadbed of this route sometimes appears as frontage roads on the northern and southern sides of the Interstate.

Along I-10 heading west to Lordsburg, sections of old US 80 are sometimes visible on the northern side of the Interstate next to the railroad tracks.

Older sections of highway can be viewed alongside the current road, including an old gradual curve in Rodeo.

South of Rodeo, US 80 travelled across the Arizona state line and continued west along SR 80 to Douglas.

[7] In 1917, the Dixie Overland Highway was established from San Diego, California to Savannah, Georgia, extending through New Mexico.

This auto trail entered New Mexico from the east through Texas, going through Roswell back into Texas to El Paso, before heading back into New Mexico through Mesilla Park, Deming and Lordsburg before aiming southwest into Arizona towards Douglas.

[8] Between 1920 and 1923, the Dixie Overland was joined by the Bankhead and Old Spanish Trail highways west of El Paso.

[16] In the 1950s, a new section of US 80 was constructed around the older route between Anthony and Las Cruces, bypassing many of the towns along the Rio Grande.

In 1991, both New Mexico and Texas requested the removal of US 80 between Anthony and Dallas, citing US 80 as being un-needed, due to being consistently multiplexed with I-10, I-20 and I-30.

On October 12, 1991, the AASHTO agreed to this proposal and truncated US 80 to its current western terminUS at I-30 in Dallas, Texas.