Democrat Tracy Mitrano challenged Republican incumbent Tom Reed in the November 6, 2018 election.

[4] Reed won reelection on November 6, 2018, retaining his seat for a fourth term.

On March 21, 2021, in light of recent sexual harassment allegations, Reed announced that he would not be seeking reelection in 2022.

Sempolinski opted not to run for a full term in the regularly scheduled 2022 election, which was won by Republican Nick Langworthy.

Scozzafava dropped out of the race just prior to the election and endorsed Democrat Bill Owens.