It runs east–west from U.S. Route 62 (US 62, named Bailey Avenue) in Buffalo to the village of Depew, where it terminates at US 20 and NY 78 (Transit Road).

NY 130 begins at an intersection with US 62 (Bailey Avenue) in the East Side of downtown Buffalo as a touring route continuation of Broadway.

NY 130 proceeds eastward through Buffalo as a four-lane commercial/industrial roadway on the south side of a railroad yard complex maintained by CSX in Schiller Park.

After the junction with CR 317, NY 130 bends southeast, crosses under the second set of railroad tracks and continues east through Depew as Broadway.

[8] The former section from Washington Street (four blocks east of Niagara Square) to US 62 is still maintained by NYSDOT as NY 954L, an unsigned reference route.