After the tracks, NY 249 darts southeast, then east through Farnham as a two-lane residential roadway, crossing the eastern village line.

In Brant, NY 249 drops the Commercial Street moniker in favor of Brant–Farnham Road, crossing an at-grade intersection with US 20 (Southwestern Boulevard).

After the Thruway, the route crosses south of Brant Town Park as it heads east as a two-lane residential roadway.

[2][4] After CR 9, NY 249 continues eastward, changing names to Brant–North Collins Road.and soon winding its way through the rural sections of Erie County.

The route crosses over Big Sister Creek and becomes residential as it enters the village of North Collins, located in the town of the same name.

This intersection serves as the eastern terminus of NY 249, whose right-of-way continues east as CR 39 (Langford Road) to the hamlet of New Oregon.