After passing through the village of Franklin, it ends at NY 28 south of Oneonta.

As it exits Unadilla to the east, it immediately crosses the Susquehanna River and enters Delaware County.

[3] Officially, only 210 feet (64 m) of NY 357's 14.06-mile (22.63 km) long routing is located within Otsego County.

From here, NY 357 progresses northeastward along the Ouleout Creek and intersects CR 14 in the hamlet of Leonta before reaching its eastern terminus at a roundabout intersection with NY 28 in an area known as North Franklin.

[2] On May 15, 2015 the NYSDOT announced plans on a project to convert the intersection with NY 28 to a roundabout.