Unlike its state-numbered predecessor, CR 380 continues south of NY 60 to the town of Busti, where it ends at a junction with Forest Avenue.

[5][6] The route continued past Redbird into the town of Stockton, where it left Cassadaga Creek and headed uphill as it curved to the west.

Here, NY 380 turned back to the north and descended into another valley surrounding the Bear Lake Outlet.

It intersected CR 37 before curving back to the north and passing through the town of Portland on its way into the village of Brocton.

Lake Erie State Park is about a few hundred feet up the road on NY 5 eastbound.

The only section of the route that was maintained by the New York State Department of Transportation was the portion between NY 424 in Stockton and US 20 in Brocton.

[9][10][11] On April 1, 1980, ownership and maintenance of NY 380's lone independent, state-maintained portion from NY 424 to the east end of its overlap with US 20 was transferred from the state of New York to Chautauqua County as part of a highway maintenance swap between the two levels of government.