The two-lane route winds westward through a rural, wooded section of Homer, ascending in elevation before crossing the Cortland–Cayuga county line.

About a mile to the north, NY 41A crosses into the hamlet of Sempronius, a small residential commune built around the junction with Phillips Road (CR 69A).

Continuing north along the western shore of the lake, NY 41A crosses through Thornton Heights and Winding Ways and passes the Skaneateles Aerodrome.

Now known as Kane Avenue, NY 41A serves several residential blocks before ending at a junction with US 20 (West Genesee Street).

[4] On January 30, 1914, the state awarded a contract to rebuild two highways leading away from SH 486 in Mandana, one heading generally southwestward for 1.7 miles (2.7 km) and another traveling southeast to the Cayuga–Onondaga county line.

The southeast leg of SH 1068 did not receive a posted route number as it did not connect to any state roads at its south end.