The town developed along the Burlington and Missouri Railroad in the late 1880s, with the commercial district taking shape between 1890 and 1952.

The district includes twenty-three buildings, primarily commercial buildings, including two properties that are separately listed on the National Register of Historic Places: the Weston County Courthouse and the Newcastle Main Post Office.

[2][3] The district lies along either side of West Main Street, also known as US Route 16, near its intersection with what is now the BNSF Railway.

The district was influenced by a series of fires that destroyed a number of buildings, which were replaced with newer buildings in styles such as Streamline Moderne, Beaux-Arts, and Mission styles, complementing pre-existing late Victorian architecture.

This article about a property in Wyoming on the National Register of Historic Places is a stub.