The Accident and Emergency Department and Intensive Care closed on 16 November 2010.

A walk-in centre for minor ailments and injuries remained on the site.

[1] The hospital was originally constructed as the infirmary for the Newcastle Union Workhouse.

[4] In 1948 the name was changed to the Newcastle General Hospital when it became part of the National Health Service.

[8] Newcastle University bought the site in 2019 and plans to develop the UK's first health innovation neighbourhood.