Newcastle House is a mansion in Lincoln's Inn Fields in central London, England.
Reconstruction of a new house – effectively the one which still stands, albeit greatly altered – to designs by Captain William Winde commenced promptly, but in 1688 the house was ransacked by a mob in consequence of Lord Powis's association with the recently deposed James II.
Holles left the house to his nephew Thomas Pelham-Holles, who was confusingly also created 1st Duke of Newcastle (his uncle's was the second creation, his the third).
Also in the early 1900s, the rear wings were removed in connection with the construction of Kingsway, a major thoroughfare which was driven through the small streets just to the west of Lincoln's Inn Fields.
Farrer & Co commissioned alternations by Sir Edwin Lutyens in the 1930s, but the building still retains much of its late 17th and early 18th century fabric and appearance.