Route 16 continues east from Aulac as an uncontrolled access 2-lane highway passing through the following communities in rural Westmorland County while paralleling the New Brunswick-Nova Scotia inter-provincial border: Point de Bute, Upper Point de Bute, Jolicure, Halls Hill, and Baie Verte Road.

From Malden to the eastern terminus at the abutment of the Confederation Bridge in Cape Jourimain, Route 16 is a controlled access 2-lane highway running on a 7 km (4.3 mi) alignment that opened in 1997.

It intersects Route 955 in a grade-separated diamond interchange approximately 1.5 km (0.93 mi) west of Bayfield.

The final interchange on Route 16 is also grade separated and provides access to the Cape Jourimain Nature Centre approximately 0.6 km (0.37 mi) west of the Confederation Bridge.

The Trans-Canada Highway and Route 16 designation was applied in the 1960s after the Bayfield and Baie Verte/Strait Shores realignments.