1 and winds along the southern and eastern coasts of Avalon Peninsula on the island of Newfoundland.

Route 10 begins in St. Vincent's-St. Stephen's-Peter's River at a bridge along the beach, which straddles a narrow isthmus between the ocean and a large lagoon (Holyrood Pond), with the road continuing west as Route 90.

It continues south along the coast to cross over the Peter's River before leaving the town and winding its way east through hilly and rural grassland.

The highway then has an intersection with St. Shott's Road, the only road access to the town of St. Shott's and Cape Pine, before passing through the towns of Trepassey, Biscay Bay, and Portugal Cove South.

Route 10 passes just north of Chance Cove Provincial Park before turning north to wind along the coastline again to pass through Renews-Cappahayden, Fermeuse (where it has an intersection with Port Kirwan Road, which provides access to Port Kirwan), Aquaforte, Ferryland, Calvert, and Cape Broyle.