Route 220 is the southern portion of the Heritage Run in the Canadian province of Newfoundland and Labrador, running along the southern and western coastlines of the Burin Peninsula of Newfoundland.

Beginning at its western end, Route 220 begins as a continuation of Route 210 (Burin Peninsula Highway/Heritage Run) at an intersection with Marine Drive at the eastern end of Grand Bank.

Route 220 bypasses the town to the south along Grandview Boulevard before leaving and heading west along the coastline for a few kilometres.

Route 220 heads eastward to pass through Calmer (minor settlement with only two dwellings)[7] and Lamaline, where a local road provides access to the village of Allan's Island.

The highway now winds its way northeast through inland rural terrain for several kilometres (where it has an intersection with local road leading to Epworth, Great Salmonier, Wandsworth, L'Anse-à-l'Eau, and Corbin) to pass through Lewin's Cove before entering Burin.