The Team Gushue Highway begins in the northwestern corner of St. John's at exit 45 of the Outer Ring Road (Trans-Canada Highway/Route 1) in a rural wooded area.

It heads south through neighbourhoods to pass under Route 50 (Thorburn Road) before having an interchange with Goldstone Street and entering a business district.

Team Gushue Highway comes to its temporary southern end shortly thereafter at an interchange with Route 60 (Topsail Road) on the St. John's-Mount Pearl city line.

Brier Avenue begins at a trumpet interchange with Team Gushue Highway and heads through rural wooded areas as a two-lane road.

There are special curling stone shields placed on the exit signs for the highway along Route 1.