It continues on through the west end of St. John's, then through the northern part of the city of Mount Pearl.

After reaching the town of Manuels, Route 60 becomes the Conception Bay Highway, continuing through Conception Bay South, Holyrood, Marysvale, Brigus and ending at the intersection of Route 70 in the town of Cupids.

Once out of the city, Route 60 also runs along the side of Conception Bay through many small rural communities.

The section from Cornwall Avenue to Water Street is often referred to as Old Topsail Road, although this is not its official name.

A large portion of the annual Tely 10 road race traces Route 60 eastbound through Paradise, Mount Pearl, and St. John's.