Named after Singaporean late entrepreneur, Ng Teng Fong, the hospital is part of an integrated development together with the adjoining Jurong Community Hospital.

It began operations on 30 June 2015[1] after JurongHealth's move from Alexandra Hospital and was officially opened on 10 October that year.

[2] Construction of the hospital started in 2012 and had cost about SGD 1 billion to build.

[3] The hospital was planned together with the Jurong Community Hospital to cater to the residents living in the Western part of Singapore and it will comprise 8 levels of specialist clinics upon completion.

[1] On 10 October that year, Ng Teng Fong General Hospital, along with Jurong Community Hospital, was officially opened at JurongHealth's Health Carnival, by guest-of-honour Prime Minister Lee Hsien Loong.