St. Luke's Hospital for the Elderly Sick was registered as a voluntary welfare organization in the Registry of Societies in October 1991.

The idea of setting up a community hospital was first mooted by a group of Christian doctors and nurses after a report from the Advisory Council on the Aged in 1988 raised important issues concerning the lack of adequate elderly care facilities in Singapore.

A projection of the number of facilities and resources needed to provide adequate healthcare services to Singapore's aging population in 2030 revealed serious shortfalls.

The groundbreaking ceremony for St Luke's Hospital took place on 6 March 1993 at the 0.78-hectare (1.9-acre) site along Bukit Batok Street 11.

[3] Minister of Parliament (MP) for Bukit Batok and patron of the hospital Dr. Ong Chit Chung officiated at the ground-breaking ceremony.

[4] In response, MP Dr. Ong Chit Chung arranged for a dialogue session between the residents and representatives from MOH and the hospital.

The panel members included Dr. Chen Ai Ju, the Deputy Director of Medical Services (Hospitals); Dr. Clarence Tan, Director (Continuing Care); and Professor Lee Hin Peng, who was the head of Community, Occupational, and Family Medicine and also vice chairman of St. Luke's Hospital.

To meet the increase in demand, the existing inpatient gymnasium was expanded, and 2 more rooms were added to the day rehabilitation center.

The Community Integration Program (CIP) was introduced in 2003 to help patients regain the confidence to ambulate in public places after a long hospitalization period.

Patients had the opportunity to visit the Singapore Zoo, Bukit Batok Nature Reserve, and a mega fun fair at the Methodist Girls School as part of the training program.

Dr. Scherer visited St. Luke's Hospital on 22 March to discuss fall risk assessment and prevention in the elderly.

Other healthcare experts like Dr. Jennifer Bottomley visited St. Luke's Hospital in 2005 and provided valuable advice regarding fall prevention in the elderly.

With the aim of keeping its staff updated with the latest developments in the medical field, St. Luke's Hospital organized a program with eleven lunchtime talks a year that focuses on healthcare for the elderly.

The outpatient clinic was commissioned by the World Health Organization (WHO) in February 2007 to be one of the three primary care establishments in Singapore to pilot the WHO age-friendly concept and toolkit.

[12] In 2004, St. Luke's Hospital, together with the Social Service Training Institute (SSTI) and the Neuro-Developmental Treatment Association (NDTA) Incorporated, organized a course to help adult stroke victims.

During the therapy sessions, patients play video games and perform simple actions repeatedly with the aim of restoring movement in their affected arm.

In 2006, the Head of Medical Services Dr. Tan Boon Yeow, and senior physiotherapist Kung Beng Keng, received the Courage Fund and Healthcare Humanity Awards.

[15] Volunteers have played a significant role in the delivery of quality healthcare services to elderly patients since St. Luke's Hospital was founded.

In 1996, more than 100 volunteer doctors, pharmacists, speech therapists, and other lay helpers helped full-time staff to keep the hospital running.

In 1996, students from Bukit Batok Secondary School raised nearly S$50,000 from a charity jogathon to purchase an ambulance for the hospital.

[19] The Methodist Girls School has also been supporting St Luke's Hospital every year since 1997 through various fund-raising efforts like food, fun fairs, music recitals, and concerts.

The Zonta Club, which is a group of women professionals, adopted St. Luke's Hospital as their ongoing community project in 1996.

In 2010, Mr. Richard Tay, a faithful volunteer at SLH, received the Rotary Club of Singapore's Good Samaritan Award.

[20] St. Luke's Hospital also holds its annual Flag Day event to raise funds to meet its operational costs.

The means test was introduced by MOH in 2000 to provide financial assistance to elderly patients who could not afford the intermediate healthcare services, especially if the period of hospitalization was long.

The centers are located at Bukit Timah, Changkat, Clementi, Hougang, Jurong East, Serangoon, Tampines, Telok Blangah, Whampoa, and Yishun.