She was a daughter of Duke Nguyễn Phúc Trung of Minh Linh Nguyễn clan and Lady Phùng of An Du Phùng Clan, Thừa Thiên district.
She married Nguyễn Phúc Luân and gave birth to three sons and one daughter.
She escaped to the very far south of Vietnam and spent most of her time in Phú Quốc and Thổ Châu.
Lady Nguyễn Thị Hoàn was invited to go back to Gia Định.
In 1812 she was elevated to the title as Hiếu Khang Empress Dowager (Ý Tĩnh Huệ Cung An Trinh Từ Hiến Hiếu Khang hoàng hậu, 懿靜惠恭安貞慈獻孝康皇后).