[2] She reported broadly on the 2016 campaign for CNN's digital and television platforms, with a special focus on identity politics—exploring the dynamics of demographics, race, and religion, and reporting on the groups of people who help shape national elections.

Henderson graduated from Lower Richland High School in Hopkins, South Carolina in 1992.

[3] Henderson began her career writing for The Baltimore Sun and then for Newsday's national staff[4] where she was its lead reporter covering Barack Obama's 2008 campaign, the Democratic primary race and the Democratic National Convention.

[5] As national political reporter for the Post, she covered the White House, the 2012 presidential campaign, the 2010 mid-term elections and anchored the Post's Election 2012 blog.

In 2015, Henderson joined CNN as senior political reporter and anchor.